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BIOPHOTONICS WORKSHOP
May 14th, 2:30-6:00pm
Co-sponsored:
MIT Center for Biomedical Innovation (CBI), BioMAN program
This workshop will explore the application of optical systems for monitoring and improving our understanding of biological processes. The session will cover different optical techniques, from imaging to spectroscopy, and their application as an analytical tool for biotechnology and pharmaceutical applications.
Among the speakers in this session are experts from academia, government and industry, bringing different perspectives on the latest research from the lab and on developments in analytical instrumentation for the field.
Panel Discussion - From the Lab Bench to the Field: Real Time Analytical Instrumentation and Potential Opportunities in Biomanufacturing
"When you can measure what you are speaking about, and express it in numbers, you know something about it; but when you cannot measure it, when you cannot express it in numbers, your knowledge is of a meager and unsatisfactory kind…." Lord Kelvin, Popular Lectures and Addresses [1891-1894]
Recent FDA initiatives have highlighted the need for increased process understanding to better optimize biomanufacturing processes; ensure patient safety; reduce manufacturing costs; and improve product quality. The FDA’s 2004 guidance on Process Analytical Technologies (PAT), has driven new efforts toward developing and improving tools for process monitoring in the pharmaceutical and biotech industry. This panel discussion will focus on opportunities and challenges in developing optical analytical tools for online monitoring applications, in particular for bioprocessing.
Optical based sensors hold great promise for bioprocess monitoring, since the technology enables noninvasive continuous monitoring of multiple components including substrate and product. Optical techniques including fluorescence, NIR, MIR and Raman spectroscopy, light scattering, and imaging, have all been explored and used to measure proteins and relevant media components during biomanufacturing processes.
Some of the questions we will explore:
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To date, PAT applications in biomanufacturing have concentrated on NIR. How effective is NIR and where are exciting opportunities beyond NIR for bioprocess monitoring?
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Today, protein characterization requires offline bench top analytical instrumentation – what will it take to bring the measurements online?
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What are the challenges translating optical sensor systems to the field – in particular the pharmaceutical manufacturing floor – where robustness requirements are extremely high?
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Workshop Agenda
Chairs:
Elizabeth J. Bruce, Center for Biomedical Innovation, MIT
Manoharan Ramasamy, Global Pharmaceutical Commercialization-PAT, Merck
2:30-2:40pm - Introduction
Invited Speakers
Session 1. From the Laboratory
2:40-3:00pm
“Recent Trend in Biomedical Optical Imaging Research – a Perspective View from Funding Support of Optical Imaging at the NIBIB/NIH”
Yantian Zhang, Ph.D., National Institute of Biomedical Imaging and Bioengineering, National Institute of Health (NIH)
3:00-3:20pm
“Spectral Interferometry in Biology and Medicine: Past, Present and Future”
Professor Michael Feld, MIT Spectroscopy Lab, MIT
3:20-3:40pm
[Novel Optical Diagnostic Tools for Studying Biomedical Problems]
Professor Peter So, Biological and Mechanical Engineering, MIT
BREAK (10 min)
Session 2. To the Field
3:50-4:10pm
[Process Analytical Technologies (PAT) and the Pharmaceutical Industry]
G.K. Raju, Ph.D. and Steve Griffiths, Ph.D., Light Pharma, Inc.
4:10-4:30pm
“Streamlining Protein-Drug Research and Formulation with Vibrational Spectroscopy”
Rina K. Dukor, Ph.D., BioTools, Inc.
4:30-4:50pm
“The Application of Dynamic Light Scattering to the Real-Time Measurement of Biological Materials”
Fraser McNeil-Watson and E. Neil Lewis, Ph.D., Malvern Instruments
BREAK (10 min)
5:00-5:45pm
Panel Discussion - From the Lab Bench to the Field: Real Time Analytical Instrumentation and Opportunities in Bioprocess Monitoring
What are the potential opportunities and challenges for optical sensor systems in biological process monitoring and for online product characterization in the biotech and pharma industry?
Panelists:
Richard Crocombe, Thermo Fisher Scientific
Rina K. Dukor, Ph.D., BioTools, Inc.
Professor Michael Feld, MIT Spectroscopy Lab
Fraser McNeil-Watson, Malvern Instruments
G.K. Raju, Ph.D., Light Pharma, Inc.
Yossi Shabtai, Ph.D., Metabolix, Inc.
Professor Peter So, Biological Engineering, MIT
Yantian Zhang, Ph.D., National Institute of Health (NIH)
5:45pm Closing Remarks
6:00pm Reception and Dinner
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